Human ETHE1 protein (Recombinant) (His-Tag) (STJP017505)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human ETHE1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ETHE1 |
| Gene ID | 23474 |
| Uniprot ID | ETHE1_HUMAN |
| Accession Number | NP_055112 |
| Immunogen | Human |
| Immunogen Region | 13-254aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus. |
| Protein Name | Persulfide Dioxygenase Ethe1 - MitochondrialEthylmalonic Encephalopathy Protein 1Hepatoma Subtracted Clone One ProteinSulfur Dioxygenase Ethe1 |
| Database Links | Reactome: R-HSA-1614517 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Matrix |
| Alternative Protein Names | Persulfide Dioxygenase Ethe1 - Mitochondrial proteinEthylmalonic Encephalopathy Protein 1 proteinHepatoma Subtracted Clone One Protein proteinSulfur Dioxygenase Ethe1 proteinETHE1 proteinHSCO protein |
Information sourced from Uniprot.org