Name: Human ERLIN2 protein (Recombinant) (N-His) (STJP003412)
SKU: STJP003412
Availability: InStock

Human ERLIN2 protein (Recombinant) (N-His) (STJP003412)

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STJP003412

$443.48 - $1,940.63

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Host:	E. coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Recombinant-Human ERLIN2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.

Formulation:	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Post Translational Modifications	Deubiquitinated by USP25.leading to stabilization.
Function	Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex.
Protein Name	Erlin-2 Endoplasmic Reticulum Lipid Raft-Associated Protein 2 Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 Spfh Domain-Containing Protein 2
Database Links	Reactome: R-HSA-382556 Reactome: R-HSA-5655302 Reactome: R-HSA-5678895 Reactome: R-HSA-8853336
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein Associated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane
Alternative Protein Names	Erlin-2 protein Endoplasmic Reticulum Lipid Raft-Associated Protein 2 protein Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 protein Spfh Domain-Containing Protein 2 protein ERLIN2 protein C8orf2 protein SPFH2 protein UNQ2441 protein PRO5003 protein PRO9924 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP005172	Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172)	E. coli
STJP004723	Human WAS protein (Recombinant) (N-His) (STJP004723)	E. coli
STJP001380	Human TET2 protein (Recombinant) (N-his) (STJP001380)	HEK293 cells
STJP003323	Human DIAPH1 protein (Recombinant) (N-His) (STJP003323)	E. coli
STJP003316	Human NPHS1 protein (Recombinant) (N-His) (STJP003316)	E. coli

Human ERLIN2 protein (Recombinant) (N-His) (STJP003412)

General Information