| Tissue Specificity | Ubiquitously expressed. Highly expressed in spleen and leukocytes. |
| Post Translational Modifications | N-glycosylated. |
| Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. |
| Protein Name | Endoplasmic Reticulum Aminopeptidase 2Leukocyte-Derived Arginine AminopeptidaseL-Rap |
| Database Links | Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative ELISA Names | Endoplasmic Reticulum Aminopeptidase 2 ELISA kitLeukocyte-Derived Arginine Aminopeptidase ELISA kitL-Rap ELISA kitERAP2 ELISA kitLRAP ELISA kit |
| output | |
Information sourced from Uniprot.org