| Host: | E.coli |
| Applications: | SDS-PAGE/Denatured |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human Epoxide Hydrolase 1/EPHX1-T7-Tag protein was developed from e.coli and has a target region of T7-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.4M urea |
| Concentration: | 0.25 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EPHX1 |
| Gene ID: | 2052 |
| Uniprot ID: | HYEP_HUMAN |
| Immunogen Region: | 21-455aa |
| Accession Number: | NP_000111 |
| Immunogen: | Human |
| Immunogen Sequence: | MASMTGGQQM GRGSHMRDKE ETLPLEDGWW GPGTRSAARE DDSIRPFKVE TSDEEIHDLH QRIDKFRFTP PLEDSCFHYG FNSNYLKKVI SYWRNEFDWK KQVEILNRYP HFKTKIEGLD IHFIHVKPPQ LPAGHTPKPL LMVHGWPGSF YEFYKIIPLL TDPKNHGLSD EHVFEVICPS IPGYGFSEAS SKKGFNSVAT ARIFYKLMLR LGFQEFYIQG GDWGSLIC |
| Tissue Specificity | Found in liver. |
| Function | Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol. Binds 20(S)-hydroxycholesterol (20(S)-OHC). |
| Protein Name | Epoxide Hydrolase 1Epoxide HydrataseMicrosomal Epoxide HydrolaseMeh |
| Database Links | Reactome: R-HSA-211945 |
| Cellular Localisation | Microsome MembraneSingle-Pass Type Iii Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Protein Names | Epoxide Hydrolase 1 proteinEpoxide Hydratase proteinMicrosomal Epoxide Hydrolase proteinMeh proteinEPHX1 proteinEPHX proteinEPOX protein |
Information sourced from Uniprot.org
