Biotinylated Human EpCAM on Tris-Bis PAGE under reduced condition. The purity is greater than 95%..

Human EpCAM/TROP1 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001637)

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STJP001637
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human EpCAM/TROP1-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: EPCAM
Gene ID: 4072
Uniprot ID: EPCAM_HUMAN
Immunogen Region: Gln24-Lys245
Immunogen: DNA sequence encoding Human EpCAM/TROP1 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.
Function May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Protein Name Epithelial Cell Adhesion Molecule
Ep-Cam
Adenocarcinoma-Associated Antigen
Cell Surface Glycoprotein Trop-1
Epithelial Cell Surface Antigen
Epithelial Glycoprotein
Egp
Epithelial Glycoprotein 314
Egp314
Hegp314
Ks 1/4 Antigen
Ksa
Major Gastrointestinal Tumor-Associated Protein Ga733-2
Tumor-Associated Calcium Signal Transducer 1
Cd Antigen Cd326
Database Links Reactome: R-HSA-202733
Cellular Localisation Lateral Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Tight Junction
Colocalizes With Cldn7 At The Lateral Cell Membrane And Tight Junction
Alternative Protein Names Epithelial Cell Adhesion Molecule protein
Ep-Cam protein
Adenocarcinoma-Associated Antigen protein
Cell Surface Glycoprotein Trop-1 protein
Epithelial Cell Surface Antigen protein
Epithelial Glycoprotein
Egp protein
Epithelial Glycoprotein 314 protein
Egp314 protein
Hegp314 protein
Ks 1/4 Antigen protein
Ksa protein
Major Gastrointestinal Tumor-Associated Protein Ga733-2 protein
Tumor-Associated Calcium Signal Transducer 1 protein
Cd Antigen Cd326 protein
EPCAM protein
GA733-2 protein
M1S2 protein
M4S1 protein
MIC18 protein
TACSTD1 protein
TROP1 protein

Information sourced from Uniprot.org

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