Human Endophilin B1/Bif-1 protein (Recombinant) (His-Tag) (STJP017909)

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STJP017909
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Endophilin B1/Bif-1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol, 2mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: SH3GLB1
Gene ID: 51100
Uniprot ID: SHLB1_HUMAN
Immunogen Region: 1-365aa
Accession Number: NP_057093.1
Immunogen: Human
Immunogen Sequence: MNIMDFNVKK LAADAGTFLS RAVQFTEEKL GQAEKTELDA HLENLLSKAE CTKIWTEKIM KQTEVLLQPN PNARIEEFVY EKLDRKAPSR INNPELLGQY MIDAGTEFGP GTAYGNALIK CGETQKRIGT ADRELIQTSA LNFLTPLRNF IEGDYKTIAK ERKLLQNKRL DLDAAKTRLK KAKAAETRNS SEQELRITQS EFDRQAEITR LLLEGISSTH AHHLRCLN
Tissue Specificity Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes.
Post Translational Modifications Phosphorylated at Thr-145 by CDK5.this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization.
Function May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2. Isoform 2 acts antiapoptotic in neuronal cells.involved in maintenance of mitochondrial morphology and promotes neuronal viability.
Protein Name Endophilin-B1
Bax-Interacting Factor 1
Bif-1
Sh3 Domain-Containing Grb2-Like Protein B1
Database Links
Cellular Localisation Cytoplasm
Golgi Apparatus Membrane
Peripheral Membrane Protein
Mitochondrion Outer Membrane
Cytoplasmic Vesicle
Autophagosome Membrane
Midbody
Association With The Golgi Apparatus Depends On The Cell Type
Following Starvation Colocalizes With Atg5 And Lc3 Autophagy-Related Protein(S)On Autophagosomal Membranes
Alternative Protein Names Endophilin-B1 protein
Bax-Interacting Factor 1 protein
Bif-1 protein
Sh3 Domain-Containing Grb2-Like Protein B1 protein
SH3GLB1 protein
KIAA0491 protein
CGI-61 protein

Information sourced from Uniprot.org

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