| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.1 EU/Mu g |
| Immunoreactivity: |
1.Measured by its binding ability in a functional ELISA. Immobilized Human CD105 at 2 Mu g/mL (100 Mu L/well) can bind Human ACVR2B with a linear range of 0.01-1.35 Mu g/mL.|2.Measured by its binding ability in a functional ELISA. Immobilized Human C |
| Gene Symbol: |
ENG |
| Gene ID: |
2022 |
| Uniprot ID: |
EGLN_HUMAN |
| Immunogen: |
Recombinant Human Endoglin/CD105 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu26-Gly586) of human Endoglin/CD105 (Accession #NP_001108225.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
ETVHCDLQPVGPERGEVTYT TSQVSKGCVAQAPNAILEVH VLFLEFPTGPSQLELTLQAS KQNGTWPREVLLVLSVNSSV FLHLQALGIPLHLAYNSSLV TFQEPPGVNTTELPSFPKTQ ILEWAAERGPITSAAELNDP QSILLRLGQAQGSLSFCMLE ASQDMGRTLEWRPRTPALVR GCHLEGVAGHKEAHILRVLP GHSAGPRTVTVKVELSCAPG DLDAVLILQGPPYVSWLID |
| Function | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3. |
| Protein Name | EndoglinCd Antigen Cd105 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Endoglin proteinCd Antigen Cd105 proteinENG proteinEND protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
