| Function | S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
| Protein Name | Ribosomal Rna Small Subunit Methyltransferase Nep118s RrnaPseudouridine(1248-N1-Methyltransferase18s Rrna Psi1248 MethyltransferaseNucleolar Protein Emg1 HomologProtein C2fRibosome Biogenesis Protein Nep1 |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Protein Names | Ribosomal Rna Small Subunit Methyltransferase Nep1 protein18s Rrna proteinPseudouridine(1248-N1-Methyltransferase protein18s Rrna Psi1248 Methyltransferase proteinNucleolar Protein Emg1 Homolog proteinProtein C2f proteinRibosome Biogenesis Protein Nep1 proteinEMG1 proteinC2F protein |
Information sourced from Uniprot.org
