| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. |
| Protein Name | Eukaryotic Translation Initiation Factor 3 Subunit IEif3iEukaryotic Translation Initiation Factor 3 Subunit 2Tgf-Beta Receptor-Interacting Protein 1Trip-1Eif-3-BetaEif3 P36 |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-72649Reactome: R-HSA-72689Reactome: R-HSA-72695Reactome: R-HSA-72702Reactome: R-HSA-72706 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Eukaryotic Translation Initiation Factor 3 Subunit I proteinEif3i proteinEukaryotic Translation Initiation Factor 3 Subunit 2 proteinTgf-Beta Receptor-Interacting Protein 1 proteinTrip-1 proteinEif-3-Beta proteinEif3 P36 proteinEIF3I proteinEIF3S2 proteinTRIP1 protein |
Information sourced from Uniprot.org
