| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.141ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description : | This DYSF Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | DYSF |
| Gene ID: | 8291 |
| Uniprot ID: | DYSF_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in skeletal muscle, myoblast, myotube and in the syncytiotrophoblast (STB) of the placenta (at protein level). Ubiquitous. Highly expressed in skeletal muscle. Also found in heart, brain, spleen, intestine, placenta and at lower levels in liver, lung, kidney and pancreas. |
| Post Translational Modifications | |
| Function | Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. |
| Protein Name | Dysferlin Dystrophy-Associated Fer-1-Like Protein Fer-1-Like Protein 1 |
| Database Links | Reactome: R-HSA-445355 |
| Cellular Localisation | Cell Membrane Sarcolemma Single-Pass Type Ii Membrane Protein Cytoplasmic Vesicle Membrane Colocalizes During Muscle Differentiation With Bin1 In The T-Tubule System Of Myotubules And At The Site Of Contact Between Two Myotubes Or A Myoblast And A Myotube Wounding Of Myotubes Led To Its Focal Enrichment To The Site Of Injury And To Its Relocalization In A Ca(2+)-Dependent Manner Toward The Plasma Membrane Colocalizes With Ahnak Ahnak2 And Parvb At The Sarcolemma Of Skeletal Muscle Detected On The Apical Plasma Membrane Of The Syncytiotrophoblast Reaches The Plasmma Membrane Through A Caveolin-Independent Mechanism Retained By Caveolin At The Plasmma Membrane With Cacna1s In The T-Tubule System Of Myotubules Accumulates And Colocalizes With Fusion Vesicles At The Sarcolemma Disruption Sites |
| Alternative ELISA Names | Dysferlin ELISA kit Dystrophy-Associated Fer-1-Like Protein ELISA kit Fer-1-Like Protein 1 ELISA kit DYSF ELISA kit FER1L1 ELISA kit |
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Information sourced from Uniprot.org