| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.141ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This DYSF Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
DYSF |
| Gene ID: |
8291 |
| Uniprot ID: |
DYSF_HUMAN |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in skeletal muscle, myoblast, myotube and in the syncytiotrophoblast (STB) of the placenta (at protein level). Ubiquitous. Highly expressed in skeletal muscle. Also found in heart, brain, spleen, intestine, placenta and at lower levels in liver, lung, kidney and pancreas. |
| Post Translational Modifications | |
| Function | Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. |
| Protein Name | DysferlinDystrophy-Associated Fer-1-Like ProteinFer-1-Like Protein 1 |
| Database Links | Reactome: R-HSA-445355 |
| Cellular Localisation | Cell MembraneSarcolemmaSingle-Pass Type Ii Membrane ProteinCytoplasmic Vesicle MembraneColocalizesDuring Muscle DifferentiationWith Bin1 In The T-Tubule System Of Myotubules And At The Site Of Contact Between Two Myotubes Or A Myoblast And A MyotubeWounding Of Myotubes Led To Its Focal Enrichment To The Site Of Injury And To Its Relocalization In A Ca(2+)-Dependent Manner Toward The Plasma MembraneColocalizes With AhnakAhnak2 And Parvb At The Sarcolemma Of Skeletal MuscleDetected On The Apical Plasma Membrane Of The SyncytiotrophoblastReaches The Plasmma Membrane Through A Caveolin-Independent MechanismRetained By Caveolin At The Plasmma MembraneWith Cacna1s In The T-Tubule System Of MyotubulesAccumulates And Colocalizes With Fusion Vesicles At The Sarcolemma Disruption Sites |
| Alternative ELISA Names | Dysferlin ELISA kitDystrophy-Associated Fer-1-Like Protein ELISA kitFer-1-Like Protein 1 ELISA kitDYSF ELISA kitFER1L1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
