Human DYNLL1 protein (Recombinant) (N-His) (STJP007317)

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STJP007317
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DYNLL1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DYNLL1
Gene ID: 8655
Uniprot ID: DYL1_HUMAN
Immunogen Region: Cys2-Gly89
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylation at Ser-88 promotes recruitment to DNA double-strand breaks (DSBs) by TP53BP1 and ability to inhibit MRE11. Phosphorylation at Ser-88 appears to control the dimer-monomer transition. it is phosphorylated at Ser-88 by PAK1, however, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.
Function Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. In addition to its role in cytoskeleton and transport, acts as a protein-protein adapter, which inhibits and/or sequesters target proteins. Involved in the response to DNA damage by acting as a key regulator of DNA end resection: when phosphorylated at Ser-88, recruited to DNA double-strand breaks (DSBs) by TP53BP1 and acts by disrupting MRE11 dimerization, thereby inhibiting DNA end resection. In a subset of DSBs, DYNLL1 remains unphosphorylated and promotes the recruitment of the Shieldin complex. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
Protein Name Dynein Light Chain 1 - Cytoplasmic
8 Kda Dynein Light Chain
Dlc8
Dynein Light Chain Lc8-Type 1
Protein Inhibitor Of Neuronal Nitric Oxide Synthase
Pin
Database Links Reactome: R-HSA-111446
Reactome: R-HSA-141444
Reactome: R-HSA-1632852
Reactome: R-HSA-2132295
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-2565942
Reactome: R-HSA-3371497
Reactome: R-HSA-380259
Reactome: R-HSA-380270
Reactome: R-HSA-380284
Reactome: R-HSA-380320
Reactome: R-HSA-5620912
Reactome: R-HSA-5620924
Reactome: R-HSA-5663220
Reactome: R-HSA-6798695
Reactome: R-HSA-6807878
Reactome: R-HSA-6811436
Reactome: R-HSA-68877
Reactome: R-HSA-8854518
Reactome: R-HSA-9609690
Reactome: R-HSA-9646399
Reactome: R-HSA-9648025
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Chromosome
Nucleus
Mitochondrion
Upon Induction Of Apoptosis Translocates Together With Bcl2l11 To Mitochondria
Recruited To Dna Double-Strand Breaks (Dsbs) By Tp53bp1 When Phosphorylated At Ser-88
Alternative Protein Names Dynein Light Chain 1 - Cytoplasmic protein
8 Kda Dynein Light Chain protein
Dlc8 protein
Dynein Light Chain Lc8-Type 1 protein
Protein Inhibitor Of Neuronal Nitric Oxide Synthase protein
Pin protein
DYNLL1 protein
DLC1 protein
DNCL1 protein
DNCLC1 protein
HDLC1 protein

Information sourced from Uniprot.org