| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human DVL2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | DVL2 |
| Gene ID: | 1856 |
| Uniprot ID: | DVL2_HUMAN |
| Immunogen Region: | Leu78-Thr250 |
| Immunogen: | Homo sapiens (Human) |
| Function | Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. |
| Protein Name | Segment Polarity Protein Dishevelled Homolog Dvl-2Dishevelled-2Dsh Homolog 2 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-201688Reactome: R-HSA-2028269Reactome: R-HSA-4086400Reactome: R-HSA-4608870Reactome: R-HSA-4641258Reactome: R-HSA-4641262Reactome: R-HSA-5099900Reactome: R-HSA-5368598Reactome: R-HSA-5663220Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-9673324 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytosolCytoplasmic VesicleNucleusLocalizes At The Cell Membrane Upon Interaction With Frizzled Family Members And Promotes Their InternalizationLocalizes To Cytoplasmic PunctaInteraction With Foxk1 And Foxk2 Induces Nuclear Translocation |
| Alternative Protein Names | Segment Polarity Protein Dishevelled Homolog Dvl-2 proteinDishevelled-2 proteinDsh Homolog 2 proteinDVL2 protein |
Information sourced from Uniprot.org