| Tissue Specificity | Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Expressed in the skin. |
| Post Translational Modifications | |
| Function | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. |
| Protein Name | Dual Serine/Threonine And Tyrosine Protein KinaseDusty Protein KinaseDusty PkRip-Homologous KinaseReceptor-Interacting Serine/Threonine-Protein Kinase 5Sugen Kinase 496Sgk496 |
| Database Links | |
| Cellular Localisation | CytoplasmCell MembraneApical Cell MembraneBasolateral Cell MembraneCell JunctionDetected At Apical Cell-Cell JunctionsColocalized With Fgf Receptors To The Cell MembraneDetected In Basolateral And Apical Membranes Of All Tubular Epithelia |
| Alternative ELISA Names | Dual Serine/Threonine And Tyrosine Protein Kinase ELISA kitDusty Protein Kinase ELISA kitDusty Pk ELISA kitRip-Homologous Kinase ELISA kitReceptor-Interacting Serine/Threonine-Protein Kinase 5 ELISA kitSugen Kinase 496 ELISA kitSgk496 ELISA kitDSTYK ELISA kitKIAA0472 ELISA kitRIP5 ELISA kitRIPK5 ELISA kitSGK496 ELISA kitHDCMD38P ELISA kit |
| output | |
Information sourced from Uniprot.org
