| Function | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes. Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle. Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells. May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3. Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG. May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation. Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1. The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity. Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing. |
| Protein Name | Desmoglein-3130 Kda Pemphigus Vulgaris AntigenPvaCadherin Family Member 6 |
| Database Links | Reactome: R-HSA-351906Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosomeCytoplasmTight Junction |
| Alternative Protein Names | Desmoglein-3 protein130 Kda Pemphigus Vulgaris Antigen proteinPva proteinCadherin Family Member 6 proteinDSG3 proteinCDHF6 protein |
Information sourced from Uniprot.org
