| Host: |
Rat/Goat |
| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
This DPP4 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Clonality: |
Monoclonal/Polyclonal |
| Conjugation: |
Unconjugated/Biotin |
| Formulation: |
Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Purification: |
Capture Purification: Protein A or G.Detection Purification: Antigen Affinity. |
| Concentration: |
0.5 mg/mL |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: |
DPP4 |
| Gene ID: |
1803 |
| Uniprot ID: |
DPP4_HUMAN |
| Immunogen: |
Capture immunogen: Recombinant Human DPP4 protein.Detection Immunogen: Recombinant Human DPP4 protein. |
| Post Translational Modifications | The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing. N- and O-Glycosylated. Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation. |
| Function | Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. (Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2. |
| Protein Name | Dipeptidyl Peptidase 4AdabpAdenosine Deaminase Complexing Protein 2Adcp-2Dipeptidyl Peptidase IvDpp IvT-Cell Activation Antigen Cd26Tp103Cd Antigen Cd26 Cleaved Into - Dipeptidyl Peptidase 4 Membrane FormDipeptidyl Peptidase Iv Membrane Form - Dipeptidyl Peptidase 4 Soluble FormDipeptidyl Peptidase Iv Soluble Form |
| Database Links | Reactome: R-HSA-381771Reactome: R-HSA-400511 |
| Cellular Localisation | Dipeptidyl Peptidase 4 Soluble Form: SecretedDetected In The Serum And The Seminal FluidCell MembraneSingle-Pass Type Ii Membrane ProteinApical Cell MembraneCell ProjectionInvadopodium MembraneLamellipodium MembraneCell JunctionMembrane RaftTranslocated To The Apical Membrane Through The Concerted Action Of N- And O-Glycans And Its Association With Lipid Microdomains Containing Cholesterol And SphingolipidsRedistributed To Membrane Rafts In T-Cell In An Interleukin-12-Dependent ActivationIts Interaction With Cav1 Is Necessary For Its Translocation To Membrane RaftsColocalized With Ptprc In Membrane RaftsColocalized With Fap In Invadopodia And Lamellipodia Of Migratory Activated Endothelial Cells In Collagenous MatrixColocalized With Fap On Endothelial Cells Of Capillary-Like Microvessels But Not Large Vessels Within Invasive Breast Ductal CarcinomaColocalized With Ada At The Cell Junction In Lymphocyte-Epithelial Cell AdhesionColocalized With Igf2r In Internalized Cytoplasmic Vesicles Adjacent To The Cell Surface |
| Alternative Antibody Pair Names | Dipeptidyl Peptidase 4 antibody pairAdabp antibody pairAdenosine Deaminase Complexing Protein 2 antibody pairAdcp-2 antibody pairDipeptidyl Peptidase Iv antibody pairDpp Iv antibody pairT-Cell Activation Antigen Cd26 antibody pairTp103 antibody pairCd Antigen Cd26 Cleaved Into - Dipeptidyl Peptidase 4 Membrane Form antibody pairDipeptidyl Peptidase Iv Membrane Form - Dipeptidyl Peptidase 4 Soluble Form antibody pairDipeptidyl Peptidase Iv Soluble Form antibody pairDPP4 antibody pairADCP2 antibody pairCD26 antibody pair |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
