Human DOK3 protein (Recombinant) (N-GST) (STJP005622)

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STJP005622
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DOK3-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DOK3
Gene ID: 79930
Uniprot ID: DOK3_HUMAN
Immunogen Region: Met57-Phe179
Immunogen: Homo sapiens (Human)
Post Translational Modifications Constitutively tyrosine-phosphorylated. On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase.
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function.
Protein Name Docking Protein 3
Downstream Of Tyrosine Kinase 3
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Alternative Protein Names Docking Protein 3 protein
Downstream Of Tyrosine Kinase 3 protein
DOK3 protein

Information sourced from Uniprot.org

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