Human DOK2 protein (Recombinant) (N-His) (STJP010701)

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STJP010701
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DOK2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DOK2
Gene ID: 9046
Uniprot ID: DOK2_HUMAN
Immunogen Region: Met1-Ala248
Immunogen: Homo sapiens (Human)
Post Translational Modifications On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2.
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation.
Protein Name Docking Protein 2
Downstream Of Tyrosine Kinase 2
P56(Dok-2
Database Links Reactome: R-HSA-210993
Reactome: R-HSA-8853659
Alternative Protein Names Docking Protein 2 protein
Downstream Of Tyrosine Kinase 2 protein
P56(Dok-2 protein
DOK2 protein

Information sourced from Uniprot.org

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