| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human DOCK4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | DOCK4 |
| Gene ID: | 9732 |
| Uniprot ID: | DOCK4_HUMAN |
| Immunogen Region: | Met1-Pro300 |
| Immunogen: | Homo sapiens (Human) |
| Function | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form. Involved in regulation of adherens junction between cells. Plays a role in cell migration. Isoform 2: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. |
| Protein Name | Dedicator Of Cytokinesis Protein 4 |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-983231 |
| Cellular Localisation | Cell MembraneCell ProjectionCytoplasmCytosolColocalizes With Epha2Rhog And Cttn/Cortactin At The Tip Of Protrusions In Migrating Cells |
| Alternative Protein Names | Dedicator Of Cytokinesis Protein 4 proteinDOCK4 proteinKIAA0716 protein |
Information sourced from Uniprot.org