Applications: | ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 0.053ng/mL |
Detection Limit: | 0.156-10ng/mL |
Short Description: | This DOCK3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: | 3 hrs |
Gene Symbol: | DOCK3 |
Gene ID: | 1795 |
Uniprot ID: | DOCK3_HUMAN |
Immunogen Region: | Ready-To-Use |
Sample Type: | tissue homogenates or other biological fluids. |
Tissue Specificity | In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles. |
Post Translational Modifications | |
Function | Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors. |
Protein Name | Dedicator Of Cytokinesis Protein 3 Modifier Of Cell Adhesion Presenilin-Binding Protein Pbp |
Database Links | Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013408 Reactome: R-HSA-9032759 Reactome: R-HSA-983231 |
Cellular Localisation | Cytoplasm |
Alternative ELISA Names | Dedicator Of Cytokinesis Protein 3 ELISA kit Modifier Of Cell Adhesion ELISA kit Presenilin-Binding Protein ELISA kit Pbp ELISA kit DOCK3 ELISA kit KIAA0299 ELISA kit MOCA ELISA kit |
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Information sourced from Uniprot.org