Human DNER protein (Recombinant) (C-hFc&His) (STJP001002)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human DNER Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg29-His637) of human DNER (Accession #NP_620711.3) fused with an Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human DNER-C-hFc&His protein was developed in hek293 cells using the region Arg29-His637. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.01 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | DNER |
| Gene ID | 92737 |
| Uniprot ID | DNER_HUMAN |
| Immunogen | Recombinant Human DNER Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg29-His637) of human DNER (Accession #NP_620711.3) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Arg29-His637 |
| Immunogen Sequence | RGSSLANPVPAAPLSAPGPC AAQPCRNGGVCTSRPEPDPQ HPAPAGEPGYSCTCPAGISG ANCQLVADPCASNPCHHGNC SSSSSSSSDGYLCICNEGYE GPNCEQALPSLPATGWTESM APRQLQPVPATQEPDKILPR SQATVTLPTWQPKTGQKVVE MKWDQVEVIPDIACGNASSN SSAGGRLVSFEVPQNTSVKI RQDATASLILLWKVTATGFQ QCSLIDGRSVTPLQASGGL |
Additional Info
| Tissue Specificity | Expressed in brain, spinal cord and adrenal gland. |
| Function | Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis. |
| Protein Name | Delta And Notch-Like Epidermal Growth Factor-Related Receptor |
| Database Links | Reactome: R-HSA-2122948 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPresent On The Membrane Of Dendrites And Cell Bodies But Excluded From Axonal MembraneAlso Found In Early Endosomes In The Somatodendritic Region |
| Alternative Protein Names | Delta And Notch-Like Epidermal Growth Factor-Related Receptor proteinDNER proteinBET proteinUNQ262 proteinPRO299 protein |
Information sourced from Uniprot.org