| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | DNER |
| Gene ID: | 92737 |
| Uniprot ID: | DNER_HUMAN |
| Immunogen Region: | Arg29-His637 |
| Immunogen: | Recombinant Human DNER Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg29-His637) of human DNER (Accession #NP_620711.3) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: | RGSSLANPVPAAPLSAPGPC AAQPCRNGGVCTSRPEPDPQ HPAPAGEPGYSCTCPAGISG ANCQLVADPCASNPCHHGNC SSSSSSSSDGYLCICNEGYE GPNCEQALPSLPATGWTESM APRQLQPVPATQEPDKILPR SQATVTLPTWQPKTGQKVVE MKWDQVEVIPDIACGNASSN SSAGGRLVSFEVPQNTSVKI RQDATASLILLWKVTATGFQ QCSLIDGRSVTPLQASGGL |
| Tissue Specificity | Expressed in brain, spinal cord and adrenal gland. |
| Function | Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis. |
| Protein Name | Delta And Notch-Like Epidermal Growth Factor-Related Receptor |
| Database Links | Reactome: R-HSA-2122948 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPresent On The Membrane Of Dendrites And Cell Bodies But Excluded From Axonal MembraneAlso Found In Early Endosomes In The Somatodendritic Region |
| Alternative Protein Names | Delta And Notch-Like Epidermal Growth Factor-Related Receptor proteinDNER proteinBET proteinUNQ262 proteinPRO299 protein |
Information sourced from Uniprot.org