| Function | Acts as a co-chaperone with HSPA8/Hsc70.required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus.the role of these structures, named DJANGOs, is still unclear. (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection. |
| Protein Name | Dnaj Homolog Subfamily B Member 12 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinNucleus MembraneLocalizes To The Endoplasmic Reticulum MembraneWhen OverexpressedForms Membranous Structures In The Nucleus(Microbial Infection) Upon Sv40 InfectionColocalizes With Bcap31Dnajc18 And Dnajb14 In Punctate Structures Within The Endoplasmic Reticulum Membrane |
| Alternative Protein Names | Dnaj Homolog Subfamily B Member 12 proteinDNAJB12 protein |
Information sourced from Uniprot.org
