Human DNAJB11 protein (Recombinant) (His-Tag) (STJP017122)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DNAJB11-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 2mM DTT, 0.1M NaCl. |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNAJB11 |
| Gene ID | 51726 |
| Uniprot ID | DJB11_HUMAN |
| Accession Number | NP_057390 |
| Immunogen | Human |
| Immunogen Region | 23-358aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGRDFYKILG VPRSASIKDI KKAYRKLALQ LHPDRNPDDP QAQEKFQDLG AAYEVLSDSE KRKQYDTYGE EGLKDGHQSS HGDIFSHFFG DFGFMFGGTP RQQDRNIPRG SDIIVDLEVT LEEVYAGNFV EVVRNKPVAR QAPGKRKCNC RQEMRTTQLG PGRFQMTQEV VCDECPNVKL VNEERTLEVE IEPGVRDGME YPFIGEGE |
Additional Info
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Contains high-mannose Endo H-sensitive carbohydrates. Cys-169, Cys-171, Cys-193 and Cys-196 form intramolecular disulfide bonds. The preferential partner for each Cys is not known. Thr-188 was reported to be phosphorylated upon DNA damage by ATM or ATR.however as this position has been shown to be in the ER lumen, the in vivo relevance is not proven. |
| Function | As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. |
| Protein Name | Dnaj Homolog Subfamily B Member 11Apobec1-Binding Protein 2Abbp-2Dnaj Protein Homolog 9Er-Associated DnajEr-Associated Hsp40 Co-ChaperoneEndoplasmic Reticulum Dna J Domain-Containing Protein 3Er-Resident Protein Erdj3Erdj3Erj3pHedjHuman Dnaj Protein 9Hdj-9Pwp1-Interacting Protein 4 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum LumenAssociated With The Er Membrane In A C-Terminally Epitope-Tagged Construct |
| Alternative Protein Names | Dnaj Homolog Subfamily B Member 11 proteinApobec1-Binding Protein 2 proteinAbbp-2 proteinDnaj Protein Homolog 9 proteinEr-Associated Dnaj proteinEr-Associated Hsp40 Co-Chaperone proteinEndoplasmic Reticulum Dna J Domain-Containing Protein 3 proteinEr-Resident Protein Erdj3 proteinErdj3 proteinErj3p proteinHedj proteinHuman Dnaj Protein 9 proteinHdj-9 proteinPwp1-Interacting Protein 4 proteinDNAJB11 proteinEDJ proteinERJ3 proteinHDJ9 proteinPSEC0121 proteinUNQ537 proteinPRO1080 protein |
Information sourced from Uniprot.org