| Post Translational Modifications | Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif. |
| Function | May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. |
| Protein Name | Dentin Matrix Acidic Phosphoprotein 1Dmp-1Dentin Matrix Protein 1 |
| Database Links | Reactome: R-HSA-3000178Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | NucleusCytoplasmSecretedExtracellular SpaceExtracellular MatrixIn Proliferating Preosteoblasts It Is NuclearDuring Early Maturation Stage Is Cytoplasmic And In Mature Osteoblast Localizes In The Mineralized MatrixExport From The Nucleus Of Differentiating Osteoblast Is Triggered By The Release Of Calcium From Intracellular Stores Followed By A Massive Influx Of This Pool Of Calcium Into The Nucleus |
| Alternative Protein Names | Dentin Matrix Acidic Phosphoprotein 1 proteinDmp-1 proteinDentin Matrix Protein 1 proteinDMP1 protein |
Information sourced from Uniprot.org
