Human DLL4 protein (Recombinant) (C-His&Avi) {Biotin} (STJP019826)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human DLL4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Pro524) of Human DLL4 (Accession #Q9NR61) fused with a C-His&Avi tag at the C-terminus.
General Information
| Short Description | Recombinant-Human DLL4-C-His&Avi protein was developed in hek293 cells using the region Ser27-Pro524. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS, 200 mM L-arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | DLL4 |
| Gene ID | 54567 |
| Uniprot ID | DLL4_HUMAN |
| Immunogen | Biotinylated Recombinant Human DLL4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Pro524) of Human DLL4 (Accession #Q9NR61) fused with a C-His&Avi tag at the C-terminus. |
| Immunogen Region | Ser27-Pro524 |
| Immunogen Sequence | SGVFQLQLQEFINERGVLAS GRPCEPGCRTFFRVCLKHFQ AVVSPGPCTFGTVSTPVLGT NSFAVRDDSSGGGRNPLQLP FNFTWPGTFSLIIEAWHAPG DDLRPEALPPDALISKIAIQ GSLAVGQNWLLDEQTSTLTR LRYSYRVICSDNYYGDNCSR LCKKRNDHFGHYVCQPDGNL SCLPGWTGEYCQQPICLSGC HEQNGYCSKPAECLCRPGWQ GRLCNECIPHNGCRHGTCS |
Additional Info
| Tissue Specificity | Expressed in vascular endothelium. |
| Function | Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis.negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. |
| Protein Name | Delta-Like Protein 4Drosophila Delta Homolog 4Delta4 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2660826Reactome: R-HSA-2691232Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-9013507Reactome: R-HSA-9013700 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Delta-Like Protein 4 proteinDrosophila Delta Homolog 4 proteinDelta4 proteinDLL4 proteinUNQ1895 proteinPRO4341 protein |
Information sourced from Uniprot.org