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Human DLL4 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001766)

Biotinylated Human DLL4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Human DLL4 is greater than 95% as determined by SEC-HPLC.
Immobilized Anti-DLL4 Antibody, hFc Tag at 1 Mu g/ml (100 Mu l/Well) on the plate. Dose response curve for Biotinylated Human DLL4, His Tag with the EC50 of 0. 33 Mu g/ml determined by ELISA.

Human DLL4 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001766)

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STJP001766

£618.50 - £1,909.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	HEK293
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human DLL4-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.

Conjugation:	Biotin
Formulation:	Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range:	Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction:	The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).

Gene Symbol:	DLL4
Gene ID:	54567
Uniprot ID:	DLL4_HUMAN
Immunogen Region:	Ser27-Pro524
Immunogen:	DNA sequence encoding Human DLL4 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.

Function	Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis.negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.
Protein Name	Delta-Like Protein 4 Drosophila Delta Homolog 4 Delta4
Database Links	Reactome: R-HSA-2122948 Reactome: R-HSA-2644606 Reactome: R-HSA-2660826 Reactome: R-HSA-2691232 Reactome: R-HSA-2894862 Reactome: R-HSA-2979096 Reactome: R-HSA-9013507 Reactome: R-HSA-9013700
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Delta-Like Protein 4 protein Drosophila Delta Homolog 4 protein Delta4 protein DLL4 protein UNQ1895 protein PRO4341 protein

Information sourced from Uniprot.org

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