Human DLG5 protein (Recombinant) (N-His) (STJP005746)

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STJP005746
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DLG5-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DLG5
Gene ID: 9231
Uniprot ID: DLG5_HUMAN
Immunogen Region: Asp1722-Asn1905
Immunogen: Homo sapiens (Human)
Function Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1. Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion. Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons.regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation.
Protein Name Disks Large Homolog 5
Discs Large Protein P-Dlg
Placenta And Prostate Dlg
Database Links Reactome: R-HSA-9013420
Reactome: R-HSA-9013424
Reactome: R-HSA-9696264
Reactome: R-HSA-9696270
Reactome: R-HSA-9696273
Cellular Localisation Cell Junction
Cell Membrane
Peripheral Membrane Protein
Postsynaptic Density
Cytoplasm
Cytoskeleton
Cilium Basal Body
Localized At Sites Of Cell-Cell Contact
Alternative Protein Names Disks Large Homolog 5 protein
Discs Large Protein P-Dlg protein
Placenta And Prostate Dlg protein
DLG5 protein
KIAA0583 protein
PDLG protein

Information sourced from Uniprot.org