Human DKK4 protein (Recombinant) (N-His) (STJP006136)

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STJP006136
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DKK4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DKK4
Gene ID: 27121
Uniprot ID: DKK4_HUMAN
Immunogen Region: Gln107-His212
Immunogen: Homo sapiens (Human)
Post Translational Modifications Appears to be not glycosylated. Can be proteolytically processed by a furin-like protease.
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Protein Name Dickkopf-Related Protein 4
Dickkopf-4
Dkk-4
Hdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-3772470
Reactome: R-HSA-5339717
Cellular Localisation Secreted
Alternative Protein Names Dickkopf-Related Protein 4 protein
Dickkopf-4 protein
Dkk-4 protein
Hdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form protein
DKK4 protein

Information sourced from Uniprot.org

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