Human DIXDC1 protein (Recombinant) (N-His) (STJP005460)

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STJP005460
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DIXDC1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DIXDC1
Gene ID: 85458
Uniprot ID: DIXC1_HUMAN
Immunogen Region: Ser485-Asn683
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on tyrosine and serine residues. Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation.
Function Positive effector of the Wnt signaling pathway.activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
Protein Name Dixin
Coiled-Coil Protein Dix1
Coiled-Coil-Dix1
Dix Domain-Containing Protein 1
Cellular Localisation Cell Junction
Focal Adhesion
Cytoplasm
Cytoskeleton
Stress Fiber
Colocalizes With Gamma-Tubulin At The Centrosome
Both During Interphase And Mitosis
Associated With Actin Stress Fiber At The Filament Ends
Isoform 2: Cytoplasm
Not Associated With Stress Fibers
Alternative Protein Names Dixin protein
Coiled-Coil Protein Dix1 protein
Coiled-Coil-Dix1 protein
Dix Domain-Containing Protein 1 protein
DIXDC1 protein
CCD1 protein
KIAA1735 protein

Information sourced from Uniprot.org