Human DIO2 (Deiodinase, Iodothyronine, Type II) Sandwich ELISA Kit Kit (STJE0008437)

Human DIO2 (Deiodinase, Iodothyronine, Type II) Sandwich ELISA Kit Kit (STJE0008437)

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STJE0008437
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.053ng/mL
Detection Limit: 0.156-10ng/mL
Short Description : This DIO2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids..
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: DIO2
Gene ID: 1734
Uniprot ID: IOD2_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Isoform 1 is expressed in the lung, trachea, kidney, heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain. Isoform 2 is expressed in the brain, heart, kidney and trachea.
Post Translational Modifications Ubiquitinated by MARCHF6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33.
Function Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Protein Name Type Ii Iodothyronine Deiodinase
5dii
Dioii
Type 2 Di
Type-Ii 5'-Deiodinase
Database Links Reactome: R-HSA-350864
Reactome: R-HSA-9844594
Cellular Localisation Membrane
Single-Pass Membrane Protein
Alternative ELISA Names Type Ii Iodothyronine Deiodinase ELISA kit
5dii ELISA kit
Dioii ELISA kit
Type 2 Di ELISA kit
Type-Ii 5'-Deiodinase ELISA kit
DIO2 ELISA kit
ITDI2 ELISA kit
TXDI2 ELISA kit
output

Information sourced from Uniprot.org

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