Human DGKH protein (Recombinant) (N-His) (STJP005659)

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STJP005659
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DGKH-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DGKH
Gene ID: 160851
Uniprot ID: DGKH_HUMAN
Immunogen Region: Asp317-Thr451
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated. Phosphorylation does not inhibit catalytic activity.
Function Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.
Protein Name Diacylglycerol Kinase Eta
Dag Kinase Eta
Diglyceride Kinase Eta
Dgk-Eta
Database Links Reactome: R-HSA-114508
Cellular Localisation Cytoplasm
Cell Membrane
Translocated From The Cytoplasm To Endosomes In Response To Stress Stimuli
Isoform 2 Is Rapidly Relocated Back To The Cytoplasm Upon Removal Of Stress Stimuli
Whereas Isoform 1 Exhibits Sustained Endosomal Association
Translocates From The Cytoplasm To The Cell Membrane In The Presence Of Active Gtp-Bound Form Of Hras
Alternative Protein Names Diacylglycerol Kinase Eta protein
Dag Kinase Eta protein
Diglyceride Kinase Eta protein
Dgk-Eta protein
DGKH protein

Information sourced from Uniprot.org

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