| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Has no apparent specificity with regard to the acyl compositions of diacylglycerol. Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination. |
| Protein Name | Diacylglycerol Kinase GammaDag Kinase GammaDiglyceride Kinase GammaDgk-Gamma |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | MembraneCytoplasmCytosolCytoskeleton |
| Alternative Protein Names | Diacylglycerol Kinase Gamma proteinDag Kinase Gamma proteinDiglyceride Kinase Gamma proteinDgk-Gamma proteinDGKG proteinDAGK3 protein |
Information sourced from Uniprot.org
