| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human DEPTOR-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | DEPTOR |
| Gene ID: | 64798 |
| Uniprot ID: | DPTOR_HUMAN |
| Immunogen Region: | Ser316-Cys409 |
| Immunogen: | Homo sapiens (Human) |
| Function | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes. DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy. In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity. |
| Protein Name | Dep Domain-Containing Mtor-Interacting ProteinHdeptorDep Domain-Containing Protein 6 |
| Cellular Localisation | Lysosome MembraneLocalizes To The Lysosomal Membrane When Associated With The Mtorc1 And Mtorc2 Complexes |
| Alternative Protein Names | Dep Domain-Containing Mtor-Interacting Protein proteinHdeptor proteinDep Domain-Containing Protein 6 proteinDEPTOR proteinDEPDC6 protein |
Information sourced from Uniprot.org