| Function | Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. |
| Protein Name | Density-Regulated ProteinDrpProtein Drp1Smooth Muscle Cell-Associated Protein 3Smap-3 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Density-Regulated Protein proteinDrp proteinProtein Drp1 proteinSmooth Muscle Cell-Associated Protein 3 proteinSmap-3 proteinDENR proteinDRP1 proteinH14 protein |
Information sourced from Uniprot.org
