Human DEFB4A protein (Recombinant) (N-GST) (STJP003230)

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STJP003230
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Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DEFB4A-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DEFB4A.DEFB4B
Gene ID: 100289462/1673
Uniprot ID: DFB4A_HUMAN
Immunogen Region: Gly24-Pro64
Immunogen: Homo sapiens (Human)
Function Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria. Antimicrobial activity against P.aruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM. Also exhibits antimicrobial activity against the yeast C.albicans. Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death. Acts as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells, such as immature dendritic cells and memory T cells.
Protein Name Defensin Beta 4a
Beta-Defensin 2
Bd-2
Hbd-2
Defensin - Beta 2
Skin-Antimicrobial Peptide 1
Sap1
Database Links Reactome: R-HSA-1461957
Reactome: R-HSA-1461973
Cellular Localisation Secreted
Alternative Protein Names Defensin Beta 4a protein
Beta-Defensin 2 protein
Bd-2 protein
Hbd-2 protein
Defensin - Beta 2 protein
Skin-Antimicrobial Peptide 1 protein
Sap1 protein
DEFB4A protein
DEFB102 protein
DEFB2 protein
DEFB4.DEFB4B protein

Information sourced from Uniprot.org

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