Human DEFA4 protein (Recombinant) (N-GST) (STJP004049)

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STJP004049
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Short Description :Recombinant-Human DEFA4-N-GST protein was developed from e.coli for the region N-GST. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:DEFA4
Gene ID:1669
Uniprot ID:DEF4_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Gly20-Asp97
Post Translational Modifications The three-dimensional structure formed by the three intramolecular disulfide bridges is indispensable for effective bacterial killing.
Function Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro). Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B.anthracis anthrax lethal factor lef. Protects blood cells against infection with HIV-1 (in vitro). Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro).
Protein Name Defensin Alpha 4
Corticostatin Hp-4
Hnp-4
Hp-4
Neutrophil Defensin 4
Database Links Reactome: R-HSA-1461973
Reactome: R-HSA-1462054
Reactome: R-HSA-6798695
Cellular Localisation Secreted
Cytoplasmic Vesicle
Secretory Vesicle
Stored As Mature Peptide In Neutrophil Granules
Alternative Protein Names Defensin Alpha 4 protein
Corticostatin Hp-4 protein
Hnp-4 protein
Hp-4 protein
Neutrophil Defensin 4 protein
DEFA4 protein
DEF4 protein

Information sourced from Uniprot.org