Human DDX4 protein (Recombinant) (N-His) (STJP006067)

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STJP006067
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DDX4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DDX4
Gene ID: 54514
Uniprot ID: DDX4_HUMAN
Immunogen Region: Asn35-Gly131
Immunogen: Homo sapiens (Human)
Function ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs.
Protein Name Probable Atp-Dependent Rna Helicase Ddx4
Dead Box Protein 4
Vasa Homolog
Database Links Reactome: R-HSA-5601884
Reactome: R-HSA-9696264
Cellular Localisation Cytoplasm
Perinuclear Region
Component Of The Meiotic Nuage
Also Named P Granule
A Germ-Cell-Specific Organelle Required To Repress Transposon Activity During Meiosis
Alternative Protein Names Probable Atp-Dependent Rna Helicase Ddx4 protein
Dead Box Protein 4 protein
Vasa Homolog protein
DDX4 protein
VASA protein

Information sourced from Uniprot.org

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