| Function | ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs. |
| Protein Name | Probable Atp-Dependent Rna Helicase Ddx4Dead Box Protein 4Vasa Homolog |
| Database Links | Reactome: R-HSA-5601884Reactome: R-HSA-9696264 |
| Cellular Localisation | CytoplasmPerinuclear RegionComponent Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During Meiosis |
| Alternative Protein Names | Probable Atp-Dependent Rna Helicase Ddx4 proteinDead Box Protein 4 proteinVasa Homolog proteinDDX4 proteinVASA protein |
Information sourced from Uniprot.org
