| Function | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes. In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes. Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77'. Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases. Involved in rRNA processing. May bind to specific miRNA hairpins. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. |
| Protein Name | Nucleolar Rna Helicase 2Dead Box Protein 21Gu-AlphaNucleolar Rna Helicase GuNucleolar Rna Helicase IiRh Ii/Gu |
| Database Links | Reactome: R-HSA-5250924Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusNucleoplasmCytoplasmCytosolMitochondrionPresent Both In Nucleolus And NucleoplasmInteraction With Jun Promotes Translocation From The Nucleolus To The NucleoplasmInteraction With Wdr46 Is Required For Localization To The NucleolusColocalizes In The Cytosol With Ddx1Dhx36 And Ticam1The Multi-Helicase-Ticam1 Complex May Translocate To The Mitochondria Upon Poly(I:c) Rna Ligand Stimulation |
| Alternative Protein Names | Nucleolar Rna Helicase 2 proteinDead Box Protein 21 proteinGu-Alpha proteinNucleolar Rna Helicase Gu proteinNucleolar Rna Helicase Ii proteinRh Ii/Gu proteinDDX21 protein |
Information sourced from Uniprot.org
