| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.059ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description : | This DDO Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | DDO |
| Gene ID: | 8528 |
| Uniprot ID: | OXDD_HUMAN |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in epithelial cells of the proximal nephron tubules in the renal cortex (at protein level). In the brain, expressed in the frontal, temporal, and occipital lobes of the cortex, hippocampus, striatum, diencephalon, brainstem, cerebellum, spinal cord, plexus choroiderus and ependyma (at protein level). Expression is increased in the prefrontal cortex of schizophrenic patients. Levels are normal in the superior frontal gyrus of patients with Alzheimer's disease. |
| Post Translational Modifications | May be S-nitrosylated. |
| Function | Selectively catalyzes the oxidative deamination of acidic amino acids. Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors. Protects the organism from the toxicity of D-amino acids. May also function in the intestine. |
| Protein Name | D-Aspartate Oxidase Dasox Daspo Ddo |
| Database Links | Reactome: R-HSA-389661 Reactome: R-HSA-9033241 |
| Cellular Localisation | Peroxisome Matrix Cytoplasm Cytosol Active In The Peroxisomal Matrix Isoform Ddo-1: Peroxisome Matrix Isoform 3: Peroxisome Matrix |
| Alternative ELISA Names | D-Aspartate Oxidase ELISA kit Dasox ELISA kit Daspo ELISA kit Ddo ELISA kit DDO ELISA kit |
| output |
Information sourced from Uniprot.org