| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
1.Measured by its binding ability in a functional ELISA. Immobilized Human DAF/CD55 at 0.5 Mu g/mL (100 Mu L/well) can bind Human CD97 with a linear range of 0.3-23.8 ng/mL.|2.Measured by its binding ability in a functional ELISA. Immobilized APC ant |
| Gene Symbol: |
CD55 |
| Gene ID: |
1604 |
| Uniprot ID: |
DAF_HUMAN |
| Immunogen Region: |
Asp35-Ser353 |
| Immunogen: |
Recombinant Human CD55/DAF Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Asp35-Ser353) of human CD55/DAF (Accession #NP_000565.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
DCGLPPDVPNAQPALEGRTS FPEDTVITYKCEESFVKIPG EKDSVICLKGSQWSDIEEFC NRSCEVPTRLNSASLKQPYI TQNYFPVGTVVEYECRPGYR REPSLSPKLTCLQNLKWSTA VEFCKKKSCPNPGEIRNGQI DVPGGILFGATISFSCNTGY KLFGSTSSFCLISGSSVQWS DPLPECREIYCPAPPQIDNG IIQGERDHYGYRQSVTYACN KGFTMIGEHSIYCTVNNDE |
| Post Translational Modifications | The Ser/Thr-rich domain is heavily O-glycosylated. |
| Function | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage. (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. |
| Protein Name | Complement Decay-Accelerating FactorCd Antigen Cd55 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-977606 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell MembraneLipid-AnchorGpi-AnchorIsoform 3: SecretedIsoform 4: SecretedIsoform 5: SecretedIsoform 6: Cell MembraneIsoform 7: Cell Membrane |
| Alternative Protein Names | Complement Decay-Accelerating Factor proteinCd Antigen Cd55 proteinCD55 proteinCR proteinDAF protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
