| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human DAAM1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | DAAM1 |
| Gene ID: | 23002 |
| Uniprot ID: | DAAM1_HUMAN |
| Immunogen Region: | Met1-Tyr250 |
| Immunogen: | Homo sapiens (Human) |
| Function | Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Together with DAAM2, required for myocardial maturation and sarcomere assembly. During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. |
| Protein Name | Disheveled-Associated Activator Of Morphogenesis 1 |
| Database Links | Reactome: R-HSA-4086400Reactome: R-HSA-5663220Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyPerinuclearColocalizes With Rhoa And Kank1 Around Centrosomes |
| Alternative Protein Names | Disheveled-Associated Activator Of Morphogenesis 1 proteinDAAM1 proteinKIAA0666 protein |
Information sourced from Uniprot.org
