| Tissue Specificity | Detected in liver. |
| Post Translational Modifications | |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis. 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol. Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives. |
| Protein Name | Cytochrome P450 7a124-Hydroxycholesterol 7-Alpha-HydroxylaseCypviiCholesterol 7-Alpha-HydroxylaseCholesterol 7-Alpha-Monooxygenase |
| Database Links | Reactome: R-HSA-192105Reactome: R-HSA-193368Reactome: R-HSA-193807Reactome: R-HSA-1989781Reactome: R-HSA-211976 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMicrosome Membrane |
| Alternative ELISA Names | Cytochrome P450 7a1 ELISA kit24-Hydroxycholesterol 7-Alpha-Hydroxylase ELISA kitCypvii ELISA kitCholesterol 7-Alpha-Hydroxylase ELISA kitCholesterol 7-Alpha-Monooxygenase ELISA kitCYP7A1 ELISA kitCYP7 ELISA kit |
| output | |
Information sourced from Uniprot.org
