| Post Translational Modifications | N-glycosylated. Palmitoylated on Cys-259 and/or Cys-260.required for proper localization to the plasma membrane. |
| Function | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. |
| Protein Name | Coxsackievirus And Adenovirus ReceptorCarHcarCvb3-Binding ProteinCoxsackievirus B-Adenovirus ReceptorHcvadr |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-202733 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinBasolateral Cell MembraneCell JunctionTight JunctionAdherens JunctionIn Epithelial Cells Localizes To The Apical Junction Complex Composed Of Tight And Adherens JunctionsIn Airway Epithelial Cells Localized To Basolateral Membrane But Not To Apical SurfaceIsoform 3: SecretedIsoform 4: SecretedIsoform 5: Secreted |
| Alternative Protein Names | Coxsackievirus And Adenovirus Receptor proteinCar proteinHcar proteinCvb3-Binding Protein proteinCoxsackievirus B-Adenovirus Receptor proteinHcvadr proteinCXADR proteinCAR protein |
Information sourced from Uniprot.org
