| Tissue Specificity | Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta. |
| Function | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. |
| Protein Name | Carboxy-Terminal Domain Rna Polymerase Ii Polypeptide A Small Phosphatase 1Nuclear Lim Interactor-Interacting Factor 3Nli-IfNli-Interacting Factor 3Small C-Terminal Domain Phosphatase 1Scp1Small Ctd Phosphatase 1 |
| Database Links | |
| Cellular Localisation | NucleusColocalizes With Rna Polymerase Ii |
| Alternative Protein Names | Carboxy-Terminal Domain Rna Polymerase Ii Polypeptide A Small Phosphatase 1 proteinNuclear Lim Interactor-Interacting Factor 3 proteinNli-If proteinNli-Interacting Factor 3 proteinSmall C-Terminal Domain Phosphatase 1 proteinScp1 proteinSmall Ctd Phosphatase 1 proteinCTDSP1 proteinNIF3 proteinNLIIF proteinSCP1 protein |
Information sourced from Uniprot.org
