| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human CSK-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | CSK |
| Gene ID: | 1445 |
| Uniprot ID: | CSK_HUMAN |
| Immunogen Region: | Met1-Leu450 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated. |
| Function | Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. |
| Protein Name | Tyrosine-Protein Kinase CskC-Src KinaseProtein-Tyrosine Kinase Cyl |
| Database Links | Reactome: R-HSA-180292Reactome: R-HSA-202427Reactome: R-HSA-354192Reactome: R-HSA-389948Reactome: R-HSA-5674135Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9013407Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9706369 |
| Cellular Localisation | CytoplasmCell MembraneMainly CytoplasmicAlso Present In Lipid Rafts |
| Alternative Protein Names | Tyrosine-Protein Kinase Csk proteinC-Src Kinase proteinProtein-Tyrosine Kinase Cyl proteinCSK protein |
Information sourced from Uniprot.org
