Tissue Specificity | |
Post Translational Modifications | May be phosphorylated by LYN. |
Function | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway. |
Protein Name | Cytokine Receptor Common Subunit BetaCdw131Gm-Csf/Il-3/Il-5 Receptor Common Beta SubunitCd Antigen Cd131 |
Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-5683826Reactome: R-HSA-5688849Reactome: R-HSA-5688890Reactome: R-HSA-912526 |
Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
Alternative ELISA Names | Cytokine Receptor Common Subunit Beta ELISA kitCdw131 ELISA kitGm-Csf/Il-3/Il-5 Receptor Common Beta Subunit ELISA kitCd Antigen Cd131 ELISA kitCSF2RB ELISA kitIL3RB ELISA kitIL5RB ELISA kit |
output | |
Information sourced from Uniprot.org