Human CORO1A protein (Recombinant) (N-His) (STJP004539)

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STJP004539
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CORO1A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CORO1A
Gene ID: 11151
Uniprot ID: COR1A_HUMAN
Immunogen Region: Arg7-Glu204
Immunogen: Homo sapiens (Human)
Post Translational Modifications phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin. Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.
Function May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
Protein Name Coronin-1a
Coronin-Like Protein A
Clipin-A
Coronin-Like Protein P57
Tryptophan Aspartate-Containing Coat Protein
Taco
Database Links Reactome: R-HSA-9636383
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Cortex
Cytoplasmic Vesicle
Phagosome Membrane
In Non-Infected Macrophages
Associated With The Cortical Microtubule Network
In Mycobacteria-Infected Macrophages
Becomes Progressively Relocalized And Retained Around The Mycobacterial Phagosomes
Retention On The Phagosomal Membrane Is Strictly Dependent On Mycobacterial Viability And Not Due To Impaired Acidification
Alternative Protein Names Coronin-1a protein
Coronin-Like Protein A protein
Clipin-A protein
Coronin-Like Protein P57 protein
Tryptophan Aspartate-Containing Coat Protein protein
Taco protein
CORO1A protein
CORO1 protein

Information sourced from Uniprot.org