Human CORIN protein (Recombinant) (N-GST) (STJP006280)

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STJP006280
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CORIN-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CORIN
Gene ID: 10699
Uniprot ID: CORIN_HUMAN
Immunogen Region: Gly70-Thr136
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated.required for processing and activation. Activated through proteolytic processing by a trypsin-like protease.cleaved into a N-terminal propeptide and an activated corin protease fragment. Different soluble forms are produced by cleavage and autocatalytic cleavage: Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10, while 160 kDa and 100 kDa soluble fragments are produced by autocatalytic cleavage. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1. A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with soluble fragments (100 kDa, 160 kDa and 180 kDa fragments).
Function Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing. Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. Isoform 2: Has weaker endopeptidase activity compared to isoform 1.
Protein Name Atrial Natriuretic Peptide-Converting Enzyme
Corin
Heart-Specific Serine Proteinase Atc2
Pro-Anp-Converting Enzyme
Transmembrane Protease Serine 10 Cleaved Into - Atrial Natriuretic Peptide-Converting Enzyme - N-Terminal Propeptide - Atrial Natriuretic Peptide-Converting Enzyme - Activated Protease Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 180 Kda Soluble Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 160 Kda Soluble Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 100 Kda Soluble Fragment
Database Links Reactome: R-HSA-5578768
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
May Easily Detach From The Endothelial Cell Membrane
Isoform 2: Cell Membrane
Less Efficiently Targeted To The Cell Membrane Compared To Isoform 1
Atrial Natriuretic Peptide-Converting Enzyme
180 Kda Soluble Fragment: Secreted
Soluble Form Produced Following Cleavage By Adam10
160 Kda Soluble Fragment: Secreted
Soluble Form Produced Following Autocatalytic Cleavage
100 Kda Soluble Fragment: Secreted
Alternative Protein Names Atrial Natriuretic Peptide-Converting Enzyme protein
Corin protein
Heart-Specific Serine Proteinase Atc2 protein
Pro-Anp-Converting Enzyme protein
Transmembrane Protease Serine 10 Cleaved Into - Atrial Natriuretic Peptide-Converting Enzyme - N-Terminal Propeptide - Atrial Natriuretic Peptide-Converting Enzyme - Activated Protease Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 180 Kda Soluble Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 160 Kda Soluble Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 100 Kda Soluble Fragment protein
CORIN protein
CRN protein
TMPRSS10 protein

Information sourced from Uniprot.org

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