Function | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B. |
Protein Name | Comm Domain-Containing Protein 5Hypertension-Related Calcium-Regulated Gene ProteinHcarg |
Database Links | Reactome: R-HSA-8951664 |
Cellular Localisation | CytoplasmNucleus |
Alternative Protein Names | Comm Domain-Containing Protein 5 proteinHypertension-Related Calcium-Regulated Gene Protein proteinHcarg proteinCOMMD5 proteinHT002 protein |
Information sourced from Uniprot.org