Human COMMD5 protein (Recombinant) (N-His) (STJP008248)

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STJP008248
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human COMMD5-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: COMMD5
Gene ID: 28991
Uniprot ID: COMD5_HUMAN
Immunogen Region: Glu32-Asp224
Immunogen: Homo sapiens (Human)
Function Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos.the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
Protein Name Comm Domain-Containing Protein 5
Hypertension-Related Calcium-Regulated Gene Protein
Hcarg
Database Links Reactome: R-HSA-8951664
Cellular Localisation Cytoplasm
Nucleus
Alternative Protein Names Comm Domain-Containing Protein 5 protein
Hypertension-Related Calcium-Regulated Gene Protein protein
Hcarg protein
COMMD5 protein
HT002 protein

Information sourced from Uniprot.org

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